Global leader in tissue oxygenation assessment Innovative point of care platform for diagnostics and personalised prevention of hypoxic conditions

Collaboration partners

Cambridge Nutranostics Ltd., CNL, is developing innovative point-of-care diagnostic tests in collaboration with leading medical science and technology centres. Medical science and development of Oxygen Carrying Capacity of blood plasma Lipoproteins (OCCL) test technology

University of Cambridge

Discovery in oxygen physiology and pathology

Harvard Medical School

Advanced theranostic clinical validation

Charite Hospital

Advanced nutranostic clinical validation

Royal Papworth Hospital

First clinical validation of the OCCL discovery

Lycotec Ltd.

Role of OCCL in health and pathology, new diagnostics and treatment

IVD Solutions

Leading US developer of dry chemistry point-of-care diagnostics

CaDi Ltd

IT and software for smartphone and wearable diagnostic

CNL - world #1 expert in tissue hypoxia

CNL competence for assessment of tissue oxygenation and its personalised support and treatment

Navigation on the market through new products and solutions for customers. Recommendations for doctorsto support the decision making

Alain Vuylsteke MD, FRCA, FFICM

Royal Papworth Hospital, UK

Dr Ivan Petyaev MD, PhD

Lycotec Cambridge, UK

Dennis S. Nielsen Professor, PhD

University of Copenhagen, Denmark

IK-Kyung Jang Professor, MD, PhD

Massachusetts General Hospital, USA

Wolfram Doehner Professor, MD, PhD

Charite Virchow-Klinikum, Germany

Thomas Hambrock MD, PhD, MBChB

Vitus Prostate Center, Germany

Yulia Romanenkova

Director of Assets management company,UK

Discovery – oxygen delivery from blood to tissue

It has been demonstrated that plasma lipoproteins can carry a significant amount of oxygen gas.

This property is due to the crystalline hydrophobic structure of lipids, which provides a more favourable environment for O2 solubility than in an aqueous medium

It has been demonstrated that plasma lipoproteins can carry a significant amount of oxygen gas.

This property is due to the crystalline hydrophobic structure of lipids, which provides a more favourable environment for O2 solubility than in an aqueous medium

In more than 10 years of clinical research, after this discovery, it was demonstrated that the oxygen-carrying capacity of lipoproteins could be affected by a number of factors, including inflammatory damage and oxidative stress

Decline in OCCL may result in a reduction of O2 supply to tissues and depression in their respiration, which together may contribute to the development of tissue hypoxia

Discovery – oxygen in plasma. How to measure it?

Challenge in obtaining of tissue oxygenation data. Oxygen transport from the blood to the tissue may be reduced or impaired due to inflammation or age-related oxidative tissue damage build-up. This would cause tissue hypoxia even with a high oxygen level in the blood

pubmed.ncbi.nlm.nih.gov Plasma oxygen during cardiopulmonary bypass: a comparison of blood oxygen levels with oxygen present in plasma lipid
1980

Focus on mitochondria as one of the key factors of longevity

1990

Free radical damage build-up in ageing

2000

Focus on telomeres as another factor affecting longevity

2010

Lipid / lipoprotein oxygen affecting tissue health and longevity

In Clinic
2020

Oxygen Carrying Capacity of plasma Lipoproteins, OCCL

Point-of-care technology transfer from wet to a dry chemistry platform
Every person can get a result in a few minutes at home – without visiting a doctor or hospital

OCCL tests can provide a recommendation as to whether the body’s protective potential has been reduced, and how lipoprotein properties, responsible for oxygen carrying capacity, can be improved.

Measuring oxygen supply to the body tissue would help to:

  • Assess and monitor health, lifestyle and its risk factors
  • Detect potential oxygenation problems even in asymptomatic cases, which would help to prevent and treat diseases in their early stages

OCCL blood test can predict transformations in our body and organs in advance, giving a time to react. There is no other convenient and reasonable way to assess it.

Dementia
No treatment
Heart Diseases
No.1 cause of death
Stroke
No.2 cause of death
Cancer
No.3 cause of death
Ageing
Low quality of life
Miscarriage
Every 1 of 4 birth
Regular health assessment for every family

The OCCL test can assess changes, which may negatively affect body functions and increase susceptibility to health risk factors - early warning detection helps to support and improve oxygen metabolism challenges

Our social objectives
  • Prevent leading causes of death Prevent or reduce severity of hypoxia-associated cardiovascular diseases, stroke, cancer, dementia (>90% of cases)
  • Improve pregnancy health, reduce child mortality Reduce risk of miscarriages (>70% caused by hypoxia)
  • Improve immunity support Enhance efficacy of vitamin D3 deficiency treatment
  • Improve quality of life Help to assess health in overweight and obese people. Support health and quality of life in older people
  • Affordable diagnostics in every household Disrupt multi-billion diagnostic industry – first-in-class new oxygenation test in point-of-care real-time format
Point-of-care diagnostics - anywhere and anytime

We believe in a future where people will easily assess their key health parameters as they now check their smartphone battery level. OCCL tests assess the tissue oxygenation level. Absolute values which could be considered by therapists as a reliable medical data. Point-of-care technology transfer from wet to a dry chemistry platform

Blood collection at home, using a kit with a cassette to analyse blood sample

Taking a photo of the developed colour in the cassette by smartphone

Immediate result by mobile application

Cardiovascular diseases are the leading cause of death globally
30M U.S. adults were diagnosed with heart disease in 2020
Someone in the United States has a stroke every 40 seconds
There were over 55M people worldwide living with dementia in 2020
1 in 3 elderly persons dies from Alzheimer’s or another form of dementia
In 2030 the prevalence rate in Japan is projected to exceed 20% nationwide
Miscarriage is the most common reason for losing a baby during pregnancy
Miscarriage rate of 10-15% in women who knew they were pregnant
23M miscarriages occur every year worldwide
OCCL Post Stroke Test

Can help to save millions of lives by early warning detection and assessing susceptibility to health risk factors

Can help to detect and assess reduction in tissue oxygenation, one of the leading factors in the development of pathologies such as stroke, cardiovascular diseases, dementia, cancer and infections

OCCL Health Pregnancy Test (Miscarriage Watch)

May help to save the lives of millions of babies

Able to measure oxygenation health particularly in groups with a history of miscarriage, the main risk factor linked to 70% of secondary miscarriages

Can give rapid information which may help to make lifestyle changes or seek medical help to maximise efforts in the prevention of millions of miscarriages

D3 Activation Test

Сan help to support immunity and essential body functions

Can help to assess tissue oxygenation which is important to support D3 activation in the liver, especially in people with a high prevalence of vitamin D deficiency such as persons with darker skin, 60+ and obesity

OCCL Fat Health Blood Test

Can help to differentiate the health status in overweight people

Can help to assess tissue oxygenation which is important to support the health of adipose tissue; up to 30% overweight people do not have metabolic health risk factors

Breast Milk Lipid Quality Test
  • The test may help to improve feeding, important micronutrients and oxygen delivery with breast milk for millions of babies. At least 40% of lactating mothers have insufficient quality of breast mil
  • Women with higher BMI tend to increase the weight even higher being pregnant, and only 30% of them won’t have a fat hypoxia
  • 70% of overweighted and obese mothers are predisposed to fat hypoxia which decrease a breast milk quality
  • The test can give rapid information that the mother needs to improve the quality of lipids in her milk to support baby digestion, immunity, cognition and the its body development
Breast Milk Lipid Quality Test
  • 2 out of 3 overweight or obese mothers have unhealthy systemic changes in their body adipose tissue and lipid metabolism including quality of the lipids in breast milk.
  • The test may help to assess these changes and to support their improvement by personalised nutrition or dietary supplementation.
  • Help to differentiate the health status in overweight people and assess tissue oxygenation which is important to support the health of adipose tissue
  • Women with higher BMI tend to increase the weight even higher being pregnant, and only 30% of them be out of risk group, and 70% of others are better to regularly check their fat hypoxia level which may lead to relevant negative outcomes
  • Unique opportunity to assess mother’s fat hypoxia at the same time with assessment of quality of breast milk during the breast feeding process, without conducting of blood tests
Management team
Our team of 30+ people located in 5 countries with HQ in Cambridge, UK
Dr. Ivan M Petyaev

CEO

Alexey Shulepov

CSO

Nigel Kyle

Chief Technology Officer

Oggi Tomic

IT and Digital Officer